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随机的三维数值幻影,以实现对乳腺癌的定量光声学计算机断层扫描的计算研究
Seonyeong Park1, Umberto Villa2, Fu Li1
1University of Illinois Urbana-Champaign, Department of Bioengineering, Urbana, Illinois, United States.
Journal of biomedical optics
|June 22, 2023
概括
一个新的框架为视听计算机断层扫描 (OAT) 乳腺癌诊断中的虚拟成像试验生成真实的数字乳腺幻影. 这使得成本效益高的系统设计可以在不进行人体试验的情况下进行评估,从而推动了OAT研究.
科学领域:
- 医疗成像医学成像
- 生物医学工程 生物医学工程
- 计算成像技术的成像
背景情况:
- 开发用于乳腺癌诊断的定量光声学计算机断层扫描 (OAT) 需要客观的系统设计评估.
- 对OAT系统原型的人体试验是昂贵的,并且在道德上具有挑战性.
- 使用数字幻影的虚拟成像试验 (VIT) 为系统评估提供了具有成本效益的替代方案.
研究的目的:
- 开发一个框架来生成现实的3D数值乳房幻影 (NBPs) 和数值损伤幻影 (NLPs).
- 为了使VIT能够在乳腺癌诊断中应用OAT.
- 为推进光声学和光学成像研究提供数据集.
主要方法:
- 扩展了FDA现有的NBPs,增强了OAT的血管建模.
- 模拟的NLP具有可行的瘤细胞,死核和血管生成.
- 对NBP和NLP进行随机分配现实的光声学组织特性.
- 创建了84个数据集,包括NBP,NLP和模拟的OAT测量.
主要成果:
- 发布了84个NBP,NLP和模拟OAT数据的数据集.
- 经过验证的NBP与乳腺血管和光学衰减的临床数据相比.
- 在OAT图像中的声学异质性影响的案例研究中证明了框架的实用性.
结论:
- 该框架增强了虚拟OAT研究的现实性.
- 它支持开发先进的图像重建和机器学习方法.
- 促进对OAT系统设计的客观评估和优化.
关键词:
数字化的乳房幽灵.声学乳房幻象 声学乳房幻象光学乳房幻影的幻影视声学计算机断层扫描 (optoacoustic computed tomography) 是一种光声学计算机断层扫描.摄影声学计算机断层扫描.虚拟成像试验 虚拟成像试验更多相关视频
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