在受污染的表面上对SARS-CoV-2的甲酸和甲酸盐的有效性
1Center for Food Safety, Department of Food Science and Technology, University of Georgia, Griffin, Georgia, USA.
Applied and environmental microbiology
|June 22, 2023
概括
低化物 (NaOCl) 和酸 (PAA) 消毒剂对SARS-CoV-2进行了测试. 在较低度和较短接触时间的表面上,PAA比NaOCl更有效,提供了潜在的更安全的替代品.
科学领域:
- 病毒学和微生物学
- 环境科学与公共卫生
- 传染病控制和控制传染病
背景情况:
- 一种呼吸道病毒的SARS-CoV-2可以通过受污染的表面 (fomites) 传播.
- 低化 (NaOCl) 和酸 (PAA) 是常见的表面消毒剂.
- 之前对SARS-CoV-2的消毒建议缺乏对实际病毒的验证.
研究的目的:
- 评估NaOCl和PAA对SARS-CoV-2的杀毒效果.
- 在不同条件下比较消毒剂的有效性 (土壤负荷,接触时间,表面).
主要方法:
- 使用ASTM标准方法进行悬浮和载体测定.
- 在不同度 (5-1,000 ppm) 和接触时间 (1-10 分钟) 中测试 NaOCl 和 PAA.
- 使用不钢 (SS) 和高密度聚乙烯 (HDPE) 作为载体表面.
- 通过使用Vero-E6细胞系的TCID50试验量化病毒.
主要成果:
- 在没有土壤负荷的情况下,NaOCl和PAA都在50ppm下实现了>3日志减少.
- 在土壤负荷的存在下,需要200 ppm的NaOCl或PAA才能减少>3个日志.
- 在1分钟接触的200ppm下,NaOCl和PAA都没有对SS或HDPE有效.
- PAA (200ppm,10分钟) 在两个表面都有效;NaOCl需要1000ppm10分钟.
结论:
- 世卫组织建议与1000ppmNaOCl接触1分钟对表面上的SARS-CoV-2无效.
- 在表面上,PAA对SARS-CoV-2具有显著的杀毒效果.
- PAA为SARS-CoV-2表面消毒提供了一个比NaOCl更安全,更环保,更有效的替代品.
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