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卵子捐赠者自我报告的卵巢过度刺激综合征:严重程度按触发器类型,取回的卵子和之前的病史
Diane M Tober1,2, Kevin Richter3, Dougie Zubizarreta4
1Department of Anthropology/Institute for Social Science Research, University of Alabama, 24b Ten Hoor Hall, Tuscaloosa, AL, 35487, USA. dtober@ua.edu.
Journal of assisted reproduction and genetics
|June 22, 2023
概括
卵巢过度刺激综合征 (OHSS) 在卵细胞捐赠者中不那么严重,用GnRH抗剂协议和少于30个卵细胞获取. 之前的OHSS严重程度预测了未来的OHSS严重程度.
科学领域:
- 生殖医学 生殖医学
- 内分泌学 在内分泌学.
- 卵细胞捐赠 卵细胞捐赠
背景情况:
- 卵巢过度刺激综合征 (OHSS) 是控制卵巢刺激以供卵细胞捐献的潜在并发症.
- 了解OHSS的风险因素对于捐赠者安全和优化捐赠周期至关重要.
研究的目的:
- 评估美国卵细胞捐赠者自我报告的OHSS经验.
- 调查OHSS严重程度与卵细胞产量,触发型和以前的OHSS病史之间的相关性.
主要方法:
- 给卵细胞捐赠者进行了一项85个问题的在线追溯调查.
- 数据收集发生在2019年2月至2020年9月期间,包括人口统计和每个周期的信息.
- 进行了后续访谈,参与者通过生育诊所,机构和在线论坛招募.
主要成果:
- 289名捐赠者提供了801个周期的数据,详细介绍了OHSS的经验.
- 与hCG或双重触发剂相比,使用GnRH主动激素触发剂报告了较轻的OHSS.
- 随后的周期中OHSS的严重程度与前期周期的严重程度密切相关.
结论:
- 在使用 GnRHa 触发剂的 GnRH 抗剂协议和在检索少于 30 个卵子时,观察到较低的 OHSS 发病率.
- 在前一个周期中患有严重OHSS的捐赠者更有可能再次患有严重OHSS.
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