一个个性化的区域酸盐抗凝血方案用于血液透析:一个现实世界的回顾性研究
Yanna Fan1, Feifei Wu1, Menglin Zou1
1Department of Nephrology, Gaoxin Hospital of The First Affiliated Hospital of Nanchang University, No. 7889, Changdong Avenue, Nanchang, 330096, Jiangxi, People's Republic of China.
International urology and nephrology
|June 22, 2023
概括
针对血液透析的个性化区域酸盐抗凝剂 (RCA) 方案是安全有效的. 这种简单,廉价的方法满足了个体患者的需求,证明值得在透析治疗中得到更广泛的采用.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 临床医学 临床医学
- 生物医学工程 生物医学工程
背景情况:
- 区域酸盐抗凝药 (RCA) 是对肝素进行血液透析的替代品.
- 个性化协议可以优化RCA的安全性和有效性.
- 标准化的RCA协议可能不适合所有患者.
研究的目的:
- 评估个人化RCA协议在血液透析中的安全性和有效性.
- 在RCA期间评估血液凝固,不良事件和酸盐剂量.
主要方法:
- 单中心,回顾性研究.
- 观察了98名接受RCA进行血液透析的患者 (2021年2月至2022年3月).
- 监测体外循环凝血,不良反应,电离和酸盐输液率.
主要成果:
- 在98名患者中进行了362次RCA,其中29例体外凝血.
- 大多数凝血事件与高凝血性有关.
- 在约80%的治疗中,酸盐输注速率偏离理论值±10%.
- 血液透析后的pH和二碳酸盐水平有所改善;在线导电性监测和凝血得分与类似的研究相当.
结论:
- 对血液透析的个性化RCA协议是安全有效的.
- 该方案是简单的,廉价的,并且可以根据个体患者的需要进行调整.
- 建议广泛采用这种个性化的RCA协议.
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