在初级退行性 mitrale regurgitation 中, mitrale regurgitant 严重程度,症状和运动能力之间的关系
Seth Uretsky1, Lillian Aldaia2, Leo Marcoff2
1Department of Cardiovascular Medicine, Gagnon Cardiovascular Institute, Morristown Medical Center/Atlantic Health System, 100 Madison Ave, Morristown, NJ, 07960, USA. seth.uretsky@atlantichealth.org.
The international journal of cardiovascular imaging
|June 22, 2023
概括
这项研究发现,额头肌吐 (MR) 的严重程度与患者的症状或运动能力之间没有直接联系. 这些发现挑战了治疗MR总是会改善病人的状况的假设.
科学领域:
- 心脏病学 心脏病学
- 心血管成像 - 心血管成像
- 临床医学 临床医学
背景情况:
- 退行性额回 (MR) 经常被认为与症状负担和运动能力下降有关.
- 然而,MR严重程度,症状和运动能力之间的确切关系仍未得到充分研究.
研究的目的:
- 调查退行性心肌吐严重程度与患者报告的症状和运动能力之间的关联.
- 评估MR严重程度在预测症状负担和运动限制方面的可靠性.
主要方法:
- 对67名患有轻度至重度退行性MR和保留左心室喷射分数的患者进行前性研究.
- 使用压力心声学,心磁共振 (CMR) 和堪萨斯城心肌病问卷 (KCCQ) 进行全面评估.
- 评估症状和运动能力与MR严重程度相关,通过心声回声和CMR确定.
主要成果:
- 报告呼吸障碍的患者KCCQ症状得分明显较低,并且与没有呼吸障碍的患者相比,预测的MET得分较低.
- 在患有呼吸障碍和没有呼吸障碍的患者之间,无论成像方式 (CMR或心声) 如何,都没有发现MR体积的显著差异.
- 根据CMR和心声学评估的严重MR患者,与没有严重MR患者相比,KCCQ症状得分或运动能力没有显著差异.
结论:
- 退行性 mitrale 排泄症的严重程度与症状的存在或运动能力的限制之间存在脱节.
- 这些发现挑战了常见的临床假设,即纠正MR将可预测地改善退行性MR患者的症状状况.
- 需要进一步的研究,以了解退行性MR症状的多因素性质.
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