在社区居住的老年人中增加跌倒风险的药物和步行表现:步行和大脑研究的探索性结果
Abdelhady Osman1,2, Mark Speechley3,4,5, Shehzad Ali3,5
1Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, N6G 2M1, Canada. aosman33@uwo.ca.
Drugs & aging
|June 22, 2023
概括
某些药物,如利尿剂和他类药物,可能会影响老年人的步行表现. 利尿剂的使用与步行速度减慢有关,而他类药物的使用与步伐时间变化增加有关,这可能会影响跌倒风险.
科学领域:
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
- 生物机械分析分析
背景情况:
- 药物使用是老年人跌的已知危险因素.
- 与跌倒风险增加药物 (FRIDs) 与跌倒有关的具体机制尚不清楚.
- 步行性能可能是连接FRID和落的关键中间因素.
研究的目的:
- 研究特定药物类别的使用与社区老年人的步行表现之间的关联.
- 评估常见的FRID如何影响步行速度和步行变化.
主要方法:
- 对345名居住在社区的老年人 (65岁以上) 进行横截面分析.
- 评估使用抗抑郁药,二,α阻断剂,β阻断剂,血管扩张剂,利尿剂,他类药物和阿司匹林.
- 使用多重线性回归,调整共变量,以检查药物类和步行速度/变量 (步行时间CV) 之间的关系.
主要成果:
- 利尿剂的使用显着与步行速度的减少有关 (B = -7.97厘米/秒,P = 0.009).
- 静止剂使用与增加步伐时间变化 (B = 0.13,P = 0.026) 有显著的关联.
- 对于其他评估的药物类别,没有发现统计学意义上的关联.
结论:
- 利尿剂使用与步行速度减慢的联系与现有的跌倒风险数据一致.
- 类他类药物与增加的步态变异性之间的关联是一个新发现,需要进一步调查.
- 这些发现提供了关于FRID对老年人步行表现的影响的初步数据,为未来的纵向研究提供了信息.
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