显而易见的扩散系数与几种肝脏内瘤的不同基因病理特征相关
Alexey Surov1, Kai Ina Eger2, Johann Potratz3,2
1Department of Radiology, Neuroradiology and Nuclear Medicine , Johannes Wesling University Hospital, Ruhr-University, Bochum, Germany. Alexey.Surov@Muehlenkreiskliniken.de.
European radiology
|June 22, 2023
概括
表面扩散系数 (ADC) 可以作为成像生物标志物用于肝癌中各种组织病理特征. 在几个肝脏恶性瘤中,ADC与瘤细胞性和瘤-肌瘤比率相关,有助于非侵入性评估.
科学领域:
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
- 医疗成像医学成像
背景情况:
- 肝脏恶性瘤的组织病理特征显著影响患者的预后和治疗策略.
- 非侵入性成像生物标志物对于表征肝脏瘤和指导临床决策至关重要.
- 从MRI获得的明显扩散系数 (ADC) 显示了反映瘤微环境特征的潜力.
研究的目的:
- 调查ADC值与关键组织病理特征之间的关联,包括细胞计数,Ki 67增殖指数,瘤-肌瘤比率 (TSR) 和瘤内淋巴细胞.
- 评估ADC作为不同类型原发性和转移性肝癌的替代影像标记物的实用性.
主要方法:
- 对149名肝活检患者进行了回顾性分析 (肝细胞癌,肝内胆管癌,结肠直肠癌,乳腺癌和胰腺癌转移).
- 平均ADC值是从活检前的1.5TMRI扫描中测量出来的.
- 计算了斯皮尔曼等级相关系数,以评估ADC与组织病理学参数 (细胞计数,Ki 67,TSR,淋巴细胞) 之间的关联.
主要成果:
- 在ADC测量中观察到出色的读者间一致性.
- 在肝细胞癌 (HCC),肝内胆管癌 (iCC) 和结直肠癌 (CRC) 转移中,ADC与瘤细胞性有显著的相关性.
- ADC反映了乳腺癌 (BC) 肝转移和iCC中的瘤-肌瘤比 (TSR),以及BC和CRC转移中的Ki 67.
- 在胰腺癌 (PC) 转移方面没有发现显著的相关性.
结论:
- ADC作为一个有价值的非侵入性成像生物标志物,用于评估各种肝脏恶性瘤中的瘤细胞性和TSR.
- ADC测量与HCC,iCC,CRC和BC肝转移中的特定基因病理特征相关.
- 在这些病变中,ADC似乎不反映内淋巴细胞计数.
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