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猪流感病毒的长期流行病学和演变,越南

Jonathan Cheung, Anh Ngoc Bui, Sonia Younas

Emerging infectious diseases

|June 22, 2023

概括

越南的猪流感病毒显示出来自进口猪的遗传混合,北美菌株 (H1-δ1a) 可能构成动物感染威胁. 持续的监测对于监测这些不断变化的流感A病毒至关重要.

科学领域:

兽医病毒学兽医病毒学
传染病流行病学传染病流行病学
一个健康研究研究.

背景情况:

由于人类,猪和鸟类之间的物种间传播,A型流感病毒对健康构成重大威胁.
众所周知,猪流感病毒 (SIV) 在全球范围内传播和重新分类,产生具有大流行潜力的新型菌株.

研究的目的:

调查2013年至2019年间在越南河内SIVs的遗传多样性和演变.
为了确定SIV基因库的起源,并评估动物传染病溢出的可能性.

主要方法:

在猪群中对SIV的长期监测.
孤立的流感A病毒菌株的全基因组测序.
遗传学分析以确定病毒的血统和起源.

主要成果:

在河内进行的SIV监测显示,来自亚洲和北美进口猪的基因库丰富.
观察到证据表明SIV血统的长期维持,持久性和重新分类.
持续丰富的H1和H3多样性是由人类和特有猪流感变种的引入所驱动的.
北美H1-δ1a菌株,具有三重重组的脊柱,已成为潜在的动物感染威胁.
H1-δ1a病毒与其他SIV基因型的同时传播引起了人类和动物健康的担忧.

结论:

越南的猪流感病毒种群是动态的,受到国际猪流动的影响.
像H1-δ1a这样的菌株的出现和传播凸显了与SIVs相关的持续的动物感染风险.
持续的基因组监测对于了解SIV演变和减轻公共卫生风险至关重要.

关键词:

在H1-δ1a病毒.猪流感病毒猪流感病毒越南越南越南越南流行病学流行病学基因组测序是指对基因组进行测序.流感流感流感流感流感人类遗传学是个学科.进行重新分类,重新分类.呼吸道感染呼吸道感染风险评估风险评估风险评估血清学监测是一种血清学监测.病毒学监测病毒学监测病毒病毒病毒病毒.动物病是动物病.

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