骨活检前的抗生素治疗是否会影响从骨培养中识别细菌病原体?
Lawrence A Lavery1, Peter A Crisologo1, Easton Ryan2
1Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, TX.
Wounds : a compendium of clinical research and practice
|June 22, 2023
概括
在骨活检之前接触抗生素不会影响诊断慢性骨髓炎 (骨感染) 的培养可靠性. 骨活检培养不论进行了活检前的抗生素给药,都会产生积极的结果,这对常见的临床实践构成了挑战.
科学领域:
- 整形外科 整形外科 整形外科
- 传染性疾病 传染性疾病
- 医学微生物学 医学微生物学
背景情况:
- 慢性骨髓炎的诊断通常依赖于骨活检培养.
- 一个常见的临床假设是,抗生素暴露会影响培养精度.
- 这种信念可能会导致在活检前拒绝必要的抗生素,可能会使患者的结果恶化.
研究的目的:
- 调查活检前抗生素给药对骨活检样本中的细菌产量的影响.
- 确定抗生素暴露是否会影响微生物培养对诊断慢性骨髓炎的可靠性.
主要方法:
- 对114名经组织学确认的慢性骨髓炎患者的回顾性分析.
- 对阳性细菌培养的骨活检样本的评估.
- 在接受抗生素和不接受抗生素的患者之间比较培养产量.
主要成果:
- 在接受抗生素 (77.9%) 和不接受抗生素 (85.7%) 的患者之间,没有观察到细菌产量的统计学上显著差异.
- 在骨活检之前的抗生素治疗时间不会影响细菌产量.
- 即使在先前接触过抗生素时,培养结果仍然可靠.
结论:
- 活检前的抗生素给药不会显著影响骨活检培养中的细菌产量.
- 临床医生可以自信地获得骨培养,即使患者已经接受了抗生素.
- 这一发现挑战了在骨活检进行培养分析之前拒绝使用抗生素的常见做法.
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