患有慢性偏性菌症的患者的铁代谢障碍
Eliana da Costa Alvarenga de Brito1, Igor Valadares Siqueira2, James Venturini1
1Graduate Program in Infectious and Parasitic Diseases, Faculty of Medicine, Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
PloS one
|June 22, 2023
概括
甲状腺核突菌 (PCM) 破坏铁的新陈代谢,导致炎症的贫血. 治疗改善了铁的参数,使其与缺铁性贫血区别开来.
科学领域:
- 菌类学 菌类学是指菌类学.
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- 帕拉科西迪奥伊多米科斯 (PCM) 是由Paracoccidioides spp.引起的.
- 主体免疫反应在PCM感染期间限制铁的可用性.
- 帕拉科西迪奥伊德斯种类 (Paracoccidioides spp.) 的一种. 它可以逃避免疫防御,并利用铁用于生长.
研究的目的:
- 评估慢性PCM患者的铁代谢.
- 在处理前和处理后评估铁参数的变化.
- 为了区分PCM相关性贫血与缺铁性贫血.
主要方法:
- 研究了39名慢性PCM患者 (2013-2021年).
- 评估血清费里,TIBC,TSAT,红血细胞,Hb,HCT,sTfR,以及sTfR/日志费里比率.
- 与C-反应蛋白和疾病严重程度相关联的铁参数.
主要成果:
- 治疗后血清费里丁降低,功能性铁参数增加.
- 在严重的PCM病例中,铁参数的变化更为明显.
- 在C-反应蛋白和Hb,RBC,HCT和铁水平之间发现了中度的相关性.
结论:
- PCM干扰功能和储存铁代谢.
- 治疗后铁参数的改善表明PCM诱导的炎症性贫血.
- 仔细评估铁的参数可以区分PCM贫血和缺铁性贫血.
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