相关实验视频

Updated: Jul 26, 2025

Visualization and Quantification of Endogenous Intra-Organelle Protein Interactions at ER-Mitochondria Contact Sites by Proximity Ligation Assays
08:27

Visualization and Quantification of Endogenous Intra-Organelle Protein Interactions at ER-Mitochondria Contact Sites by Proximity Ligation Assays

Published on: October 20, 2023

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线粒素2的拼接变体塑造了内质网膜,并将其与线粒体结合起来

Déborah Naón1,2,3, María Isabel Hernández-Alvarez4,5,6, Satoko Shinjo1,2

  • 1Department of Biology, University of Padua, 35121 Padova, Italy.

Science (New York, N.Y.)
|June 22, 2023
PubMed
概括

研究人员发现了ERMIT2,一种内质网膜 (ER) 蛋白质,它结合了ER和线粒体. 这种相互作用对细胞功能至关重要,并改善了小鼠的肝病,揭示了线粒素2 (MFN2) 变体的新型外线粒体作用.

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Study of Endoplasmic Reticulum and Mitochondria Interactions by In Situ Proximity Ligation Assay in Fixed Cells09:34

Study of Endoplasmic Reticulum and Mitochondria Interactions by In Situ Proximity Ligation Assay in Fixed Cells

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Translocation of Proteins into the Mitochondria01:19

Translocation of Proteins into the Mitochondria

Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
Sorting of outer membrane proteins:
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The Inner Mitochondrial Membrane01:28

The Inner Mitochondrial Membrane

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