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广谱小分子抑制剂向弗拉维病毒NS5甲基转移酶的SAM结合部位

Subodh Kumar Samrat1, Qamar Bashir1, Yiding Huang1

  • 1Department of Pharmacology and Toxicology, R Ken Coit College of Pharmacy, The University of Arizona, 1703 E Mabel St, Tucson, Arizona 85721-0207, United States.

ACS infectious diseases
|June 22, 2023
PubMed
概括

研究人员确定了两种新型化合物NSC 111552和288387,它们抑制了弗拉维病毒甲基转移酶活性. 这些潜在的宽频抑制剂在治疗登革热和寨卡病毒等感染方面表现有前途.

关键词:
在 NS5 NS5 NS5 NS5广泛的频谱广泛的频谱.弗拉维病毒 (flavivirus) 是一种病毒.高吞吐量选的高吞吐量选甲基转移酶的使用方法

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