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在胎盘和妊娠并发症中PFAS度的水平

Luda Groisman¹, Tamar Berman², Anna Quinn³

¹National Public Health Laboratory, Israel Ministry of Health, Tel Aviv, Israel.

Ecotoxicology and environmental safety

|June 22, 2023

概括

怀孕期间暴露于per-和多基物质 (PFAS) 是一个越来越令人担忧的问题. 这项研究在胎盘组织中发现了PFAS,与妊娠并发症相关的 perfluorooctanoic acid (PFOA) 的升高.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
生殖健康生殖健康

背景情况:

越来越多的担忧是暴露在per-和多基物质 (PFAS) 的健康影响.
专注于关键的发育时期,如怀孕.
需要调查PFAS在胎盘组织中的存在和影响.

研究的目的:

为了调查 PFAS 在胎盘组织中的存在.
探索PFAS对怀孕结果的潜在影响.

主要方法:

在以色列南部的50名妇女的胎盘组织中测量了13种PFAS化合物.
包括10名怀孕并发症的妇女和40名匹配的对照.
使用条件逻辑回归来分析关联.

主要成果:

检测到5种PFAS化合物 (PFOS,PFOA,PFHxS,PFNA,PFDA),其度与国际数据相比.
胎盘PFOA度升高与妊娠并发症相关 (OR=1.82).
在受研究的人群中,PFAS暴露很普遍.

结论:

这项试点研究证实了在以色列孕妇的胎盘组织中广泛的PFAS暴露.
调查结果强调需要进一步的研究和国家生物监测.
表明PFAS和不良妊娠结果之间的潜在联系.

关键词:

糖尿病糖尿病糖尿病一般人口一般人口.在PFAS中,有很多方法.胎盘胎盘胎盘胎盘怀孕并发症怀孕并发症

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