巴西SARS-CoV-2的血清流行:系统性审查和元分析
Gerusa Maria Figueiredo1, Fátima Mitiko Tengan2, Sergio Roberto Campos1
1Departamento de Medicina Preventiva da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
Clinics (Sao Paulo, Brazil)
|June 22, 2023
概括
这项系统性审查发现,在接种疫苗之前,巴西的SARS-CoV-2 (严重急性呼吸系统综合征冠状病毒2) 血清流行率达到11%,因地区和人口群体而异. 这些发现突出了病毒.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 在疫苗引入之前,巴西的SARS-CoV-2 (严重急性呼吸系统综合征冠状病毒2) 感染的传播需要了解人口暴露.
- 血清发病率数据为超出报告病例的病毒循环的实际程度提供了关键的见解.
研究的目的:
- 在疫苗普及之前,在巴西进行的SARS-CoV-2血清流行调查进行系统审查和元分析.
- 估计整体血清流行率并确定不同地区和人口群体之间的差异.
主要方法:
- 一个系统的审查和元分析,遵循PRISMA指南.
- 在巴西的血清学调查中搜索了Medline,Embase和LILACS数据库 (2019年10月 - 2021年11月).
- 包括样本大小≥50的研究,由于预期异质性,使用随机效应模型进行分析.
主要成果:
- 包括54篇出版物,包括135项调查,涉及336620名参与者.
- 总体估计的SARS-CoV-2血清流行率为11.0%,具有显著的异质性 (I2 = 99.55%).
- 亚组分析显示,献血者患病率为13.0%,基于人口的调查为9.0%,学生为13.0%,医疗保健工作者为11.0%.
结论:
- 巴西的SARS-CoV-2血清流行率随着时间的推移而增加,并表现出显著的区域差异,在北方较高,在南方下降.
- 这些发现对于分析疫苗接种前的SARS-CoV-2传播,了解其对临床表现的影响以及评估未来疫苗接种计划的有效性至关重要.
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