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皮质网络之间的功能连接变化与创伤暴露的女性的抑制控制相关

Marissa Yetter¹, Carissa L Philippi¹, Steven E Bruce¹

¹Department of Psychological Sciences, University of Missouri-St. Louis, 1 University Blvd., St. Louis, MO, 63121, USA, University of Missouri - St. Louis.

Psychiatry research. Neuroimaging

|June 22, 2023

概括

这项研究发现,通过Stroop任务测量创伤暴露女性的更好的抑制控制与创伤后应激障碍 (PTSD) 症状较少相关. 具体来说,中央执行网络 (CEN) 和默认模式网络 (DMN) 之间的连接性下降与认知功能的改善有关.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
认知心理学认知心理学

背景情况:

创伤后应激障碍 (PTSD) 与受损的抑制控制和改变的大脑网络连接性有关.
在遭受创伤的人群中,包括患有PTSD的人群中,抑制控制和休息状态功能连接 (rsFC) 的研究有限.

研究的目的:

研究 PTSD 和没有 PTSD 的女性创伤幸存者的默认模式网络 (DMN),中央执行网络 (CEN) 和突出网络 (SN) 中的抑制控制和 rsFC 之间的关系.
探索如何在认知任务上的表现与具有人际创伤史的个体的大脑网络相互作用有关.

主要方法:

利用颜色-词语Stroop任务来评估67名暴露于人际创伤的女性参与者的抑制控制.
进行了两次静止状态功能磁共振成像 (fMRI) 扫描.
在DMN,CEN和SN中进行了voxelwise rsFC分析,然后进行线性回归来将抑制控制与网络连接联系起来.

主要成果:

在Stroop任务上的更好的表现与整体PTSD症状严重程度有负面关联.
改善的抑制控制与较少的复发和过度兴奋症状相关,但没有避免症状.
减少CEN和DMN之间的功能连接与增强的抑制控制有关.

结论:

研究结果表明,在CEN和DMN之间高效切换可能支受创伤影响的个体更好的认知和注意力表现.
这项研究强调了PTSD和创伤暴露的背景下大脑网络动态和抑制控制缺陷之间的相互作用.
结果为患有PTSD的个体的认知功能提供了神经生物学见解.

关键词:

经典的斯特鲁普经典的斯特鲁普功能连接性的功能连接性.抑制性控制是一种抑制性控制.创伤后应激障碍创伤后应激障碍

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