在MS中母乳养是否有害? 来自现实世界捷克数据的答案
Pavel Hradilek1, Olga Zapletalova1, Petra Hanulikova2
1Faculty of Medicine, Ostrava University, Czech Republic; Department of Neurology, University Hospital Ostrava, Czech Republic.
Multiple sclerosis and related disorders
|June 22, 2023
概括
对于患有多发性硬化症 (MS) 的女性来说,母乳养是安全的,并且不会对其疾病的发展产生负面影响. 患有多发性硬化症的妇女可以继续母乳养,即使没有疾病修饰治疗 (DMT),也不会恶化他们的病情.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 生殖医学 生殖医学
背景情况:
- 哺乳对多发性硬化症 (MS) 进展的影响尚不清楚.
- 来自捷克国家登记处 (ReMuS) 的现实世界数据分析了患有MS的母乳养妇女.
研究的目的:
- 确定影响MS患者开始母乳养的因素.
- 评估母乳养对多发性硬化症病程的影响.
- 评估MS患者母乳养的安全性.
- 根据母乳养状态来比较MS疾病的活动.
主要方法:
- 倾向性得分匹配被用来比较母乳养和非母乳养的MS患者.
- 分析的关键指标包括扩展残疾状态量表 (EDSS),确诊疾病恶化 (CDW) 和年度复发率 (ARR).
- 根据疾病持续时间,怀孕前疾病修饰治疗 (DMT) 和怀孕前EDSS和ARR进行了比较.
主要成果:
- 分析包括从2013年到2020年期间1681次怀孕.
- 两组之间没有观察到ARR,EDSS变化或6个月CDW的显著差异.
- 患有多发性硬化症的母乳养妇女的临床结果与非母乳养妇女的临床结果相似,这些妇女在分娩后早期恢复了DMT,即使没有使用DMT.
结论:
- 在捷克共和国,患有多发性硬化症的妇女的母乳养没有对疾病的发展产生不利影响,因此建议母乳养.
- 多发性硬化症患者在服用某些DMT时可以母乳养,如果临床稳定,不需要停止母乳养.
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