基于卡帕-卡拉基南的混合水凝用于软组织工程应用
F Safarpour1, M Kharaziha1, H Mokhtari2
1Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.
Biomedical materials (Bristol, England)
|June 22, 2023
概括
红血细胞膜 (RBCM) 囊泡增强甲基酸卡帕-卡拉基安水凝用于组织工程. 这些载有RBCM的水凝显示出改善的机械性能和可控释放的疏水药物,如黄素.
科学领域:
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
- 药物输送系统 药物输送系统
背景情况:
- 细胞衍生的膜囊泡为分子输送提供了多功能平台.
- 红细胞膜 (RBCM) 具有适合生物材料应用的固有功能.
研究的目的:
- 开发一种使用RBCM囊泡和甲基烯酸卡帕-卡拉 (KaMA) 的新型复合水凝,用于软组织工程.
- 调查RBCM囊泡结合对水凝特性和治疗剂输送的影响.
主要方法:
- 制造具有不同RBCM囊泡含量的KaMA水凝.
- 在压力和循环负荷下对水凝的机械特征.
- 卷黄素 (CUR) 的封装和体外释放研究.
- 在体外评估纤维细胞活力和增殖.
主要成果:
- 加入RBCM显著提高了水凝的压力强度 (103 ± 26 kPa至257 ± 18 kPa) 和性 (1.0 ± 0.4 kJ m−3至4.0 ± 0.5 kJ m−3).
- 在三天内观察到封装库尔库的受控释放.
- 复合水凝在体外支持纤维细胞细胞的生长和增殖.
结论:
- 卡马/RBCM水凝具有可调节的机械性能和受控的疏水性药物释放能力.
- 这些发现突显了RBCM功能化水凝在先进软组织工程应用中的潜力.
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