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Updated: Jul 26, 2025

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基因毒性化物应激过早衰老血造干细胞以p53驱动的方式

Meng Wang1, Laura T L Brandt2, Xiaonan Wang3

  • 1Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA; Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK; MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, UK.

Molecular cell
|June 22, 2023
PubMed
概括

代谢衍生型甲会在造血干细胞 (HSC) 中引起DNA损伤,激活p53反应并加速衰老. 这种损伤导致HSC具有老化特征和髓状细胞分化偏差.

关键词:
造成的DNA损伤是DNA损伤.对DNA损伤的反应反应.老化的老化 衰老的老化阿尔德化物是什么意思血液形成 血液形成骨髓质偏差偏差是什么意思在 p53 里,p53 是一个 p53 的类型.

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