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在乌干达的婴儿中感染Paenibacillus spp感染后传染性水脑病:一项观察病例控制研究

Sarah U Morton¹, Christine Hehnly², Kathy Burgoine³

¹Division of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.

The Lancet. Microbe

|June 22, 2023

概括

在乌干达,Paenibacillus细菌会导致新生儿败血症和脑膜炎,导致感染后的水脑炎. 怀疑是环境暴露,而不是母婴传播,强调需要进一步研究.

科学领域:

医学微生物学医学微生物学
儿童传染病儿童传染病
新生儿健康新生儿健康

背景情况:

Paenibacillus thiaminolyticus被确定为乌干达婴儿感染后脑病的原因.
需要对Paenibacillus spp.进行调查. 作为新生儿败血症,脑膜炎和后感染性水脑病的病原体.

研究的目的:

确定Paenibacillus spp.的作用. 在新生儿败血症,脑膜炎和乌干达婴儿的后感染性水脑炎.
在母婴新生儿对中评估产周发病率.
在新生儿和婴儿的血液和脑脊液 (CSF) 中评估Paenibacillus的存在.

主要方法:

在乌干达 (2016-2019) 的母亲-新生儿对,败血症新生儿和水头的婴儿的观察研究 (2016-2019).
采集样本包括母体血液,阴道抽样,胎盘组织,带血液,新生儿血液和婴儿CSF.
分析涉及Paenibacillus和16S rDNA测序的定量PCR (qPCR) 用于CSF的细菌表征.

主要成果:

没有Paenibacillus spp. 在母体或带样本中检测到,排除了跨胎盘传播.
帕尼巴西勒斯种类 (Paenibacillus spp.) 的一种. 在6%的新生儿中发现了败血症,其中14%的新生儿患有感染后的水脑病.
帕尼巴西勒斯种类 (Paenibacillus spp.) 的一种. 是患有后感染性头症 (44%) 的婴儿中主导的细菌,与脑膜炎进展相关.

结论:

帕尼巴西勒斯种类 (Paenibacillus spp.) 的一种. 是乌干达新生儿败血症和脑膜炎的重要原因,导致后感染性水头.
地理聚类表明新生儿感染的环境来源.
进一步的研究对于确定感染途径和改进治疗以减少发病率和死亡率至关重要.

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