库尔库明纳米晶自稳定皮克林乳液冷干粉:发展,特征和抑制呼吸道炎症
Xinli Wang1, Zhenggen Liao2, Guowei Zhao2
1Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, People's Republic of China; Jiangxi Medical Device Testing Center, Nanchang 330029, People's Republic of China.
International journal of biological macromolecules
|June 22, 2023
概括
这项研究开发了一种新型的黄素纳米晶体自我稳定皮克林乳液冷干粉 (Cur-NSSPE-FDP) 来克服黄素.
科学领域:
- 纳米技术纳米技术
- 药理学 药理学是指药理学的学科.
- 材料科学 材料科学 材料科学
背景情况:
- 黄素表现出强大的抗炎性质,但其口服生物可用性较差.
- 低水溶性和透性限制了黄素在治疗呼吸道炎症等疾病中的临床用途.
研究的目的:
- 为了提高黄素的口服生物可用性和抗炎疗效,用于治疗呼吸道炎症.
- 开发和描述一个库尔库纳米晶体自我稳定皮克林乳液冷干粉 (Cur-NSSPE-FDP).
主要方法:
- 库尔库纳米晶自稳定皮克林乳液 (Cur-NSSPE) 通过高压同质化制备.
- 经过冷干燥的Cur-NSSPE,可以得到Cur-NSSPE-FDP.
- 在体外释放,细胞吸收,Caco-2细胞运输,药理动力学和体内抗炎研究.
主要成果:
- 现在的NSSPE-FDP表现出球形的核心外结构和一个多孔的网络.
- 在大鼠体内显著改善曲素的释放和口服生物可用性.
- 增强细胞吸收和Caco-2细胞运输.
- 在体外和体内证明有强大的炎症因子抑制 (NO,IL-6,TNF-α,MDA,IgE,ICAM-1) 和改善的抗氧化剂标志物 (IL-10,SOD).
结论:
- 库尔-NSSPE-FDP有效地提高了库尔库的口服生物可用性.
- 开发的配方显示出由于改善的抗炎和抗氧化作用,对呼吸道炎症具有显著的治疗潜力.
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