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主体生物标志物用于早期识别严重的进口Plasmodium falciparum疟疾

L Balerdi-Sarasola¹, C Parolo¹, P Fleitas¹

¹ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.

Travel medicine and infectious disease

|June 22, 2023

概括

通过使用新的生物标志物,可以改善严重的进口疟疾诊断. 结合的angiopoietin-2 (Ang-2) 和C反应蛋白 (CRP) 在识别严重病例方面显示出高准确性,可能减少并发症.

科学领域:

* 传染病传染病
* 临床诊断临床诊断临床诊断
* 生物标志物研究

背景情况:

严重的进口疟疾 (Plasmodium falciparum) 在非流行地区带来了显著的死亡风险.
*目前世界卫生组织 (WHO) 的标准预测严重的疟疾并发症不足.
* 需要新的生物标志物来改善进口疟疾病例的风险分层.

研究的目的:

* 评估血管蛋白-1 (Ang-1),血管蛋白-2 (Ang-2),溶性触发受体在髓状细胞 (sTREM-1),C反应蛋白 (CRP) 和血小板上表达的有效性,作为严重进口疟疾的生物标志物.
* 评估这些生物标志物的表现与修改的世卫组织严重性分类相结合.

主要方法:

*在巴塞罗那 (2011-2021) 进行的一项病例对照研究包括确诊的P. falciparum*疟疾患者和非疟疾发烧的对照患者.
*对Ang-1,Ang-2,sTREM-1,CRP和血小板的度进行测量和比较.
*生物标志物的表现使用修改的世卫组织严重性标准和多重归算模型进行评估.

主要成果:

* Ang-2和CRP在经过修改的世卫组织分类时表现出最高的诊断性能 (AUROC分别为0.79和0.80).
* Ang-2和CRP的组合模型实现了最佳的AUROC0.84,灵敏度为84.6%,特异性为77.4%.
* 在严重疟疾,无并发性疟疾和非疟疾发烧组之间观察到生物标志物水平的显著差异,除了sTREM-1.

结论:

*Ang-2和CRP的组合显示出作为早期识别严重进口疟疾的可靠工具的希望.
* 结合Ang-2和CRP的快速预后测试可以优化患者管理.
*实施此类测试可能会减少与进口疟疾相关的并发症和住院.

关键词:

生物标志物生物标志物诊断诊断诊断诊断诊断进口的疟疾.严重的疟疾严重的疟疾

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