肝脏疾病是心血管结果的重要危险因素 - 英国生物银行研究
Adriana Roca-Fernandez1, Rajarshi Banerjee2, Helena Thomaides-Brears1
1Perspectum Ltd., Oxford, United Kingdom.
Journal of hepatology
|June 22, 2023
概括
通过铁校正的T1映射 (cT1) 检测到的肝病的早期症状显著增加了主要心血管疾病 (CVD) 事件和全因死亡率的风险. 这凸显了监测肝脏健康对于心血管风险评估的重要性.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 医疗成像医学成像
- 公共卫生 公共卫生
背景情况:
- 慢性肝病 (CLD) 是心血管疾病 (CVD) 的已知危险因素.
- 早期发现肝病可能有助于预测心血管疾病风险.
- 铁校正T1映射 (cT1) 是一种新的MRI技术,用于评估肝脏疾病的活性.
研究的目的:
- 研究通过cT1测量早期肝病与重大心血管疾病事件风险之间的关联.
- 探索肝病活动对心血管结果和全因死亡率的预测价值.
- 评估这种关联是否在没有代谢综合征的个体中持续存在.
主要方法:
- 利用了来自33616名参与者的英国生物库成像数据 (2016-2020年).
- 使用LiverMultiScan® MRI测量肝脏脂肪 (PDFF) 和肝脏疾病活动 (cT1).
- 采用多变量考克斯回归来分析与心血管疾病事件,住院和死亡率的关联,并根据临床因素进行调整.
主要成果:
- 肝脏疾病活动 (cT1),但不是肝脏脂肪 (PDFF),与增加主要心血管疾病事件的风险 (HR 1.14),心房动 (HR 1.30),心力衰竭 (HR 1.30),心血管疾病住院 (HR 1.27) 和全因死亡率 (HR 1.19) 有显著关联.
- FIB-4指数显示与心力衰竭 (HR 1.06) 有关.
- 在没有代谢综合征的个体中,cT1仍然是心血管疾病住院的独立预测因素 (HR 1.26).
结论:
- 通过cT1评估的肝病活性,是发生心血管疾病和全因死亡率的独立预测指标.
- 这种关联甚至在没有被诊断的代谢综合征,肝纤维化或显著的肝脂肪的情况下也很明显.
- 综合性肝脏健康评估对于心血管疾病风险分层至关重要,为早期干预提供了机会.
关键词:
在心房纤维化.在CVD中,CVD是非常重要的.一个心脏病患者的心脏病.心脏衰竭是因为心脏衰竭.肝脏病 肝脏病是一种肝脏病.肝脏疾病是一种肝脏疾病.这就是为什么MRI是MRI.这是NAFLD.影像成像技术 影像成像技术更多相关视频
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