本质灰色物质连接的差异及其在自闭症谱系障碍中的基因组基础
Johanna Leyhausen1, Tim Schäfer2, Caroline Gurr2
1Department of Child and Adolescent Psychiatry, University Hospital, Goethe University, Frankfurt am Main, Germany; Brain Imaging Center, Goethe University, Frankfurt am Main, Germany; Department of Biosciences, Goethe University Frankfurt, Frankfurt am Main, Germany.
Biological psychiatry
|June 22, 2023
概括
这项研究揭示了自闭症患者内在脑电缆成本的差异,特别是在前额和部区域. 这些发现将自闭症神经解剖学与遗传因素联系起来,为这种疾病的异质性提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 发展障碍 发展障碍 发展障碍
背景情况:
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况,其特点是显著的异质性.
- 大脑连接的差异是自闭症的一个标志,之前的研究集中在白质上.
- 新出现的证据表明,通过布线成本评估的内在灰质连接也可能在ASD中发生变化.
研究的目的:
- 调查自闭症个体灰色质中的内在全球和本地布线成本.
- 为了确定特定的大脑区域显示出自闭症和神经类型个体之间的内在连接的差异.
- 探索自闭症中观察到的神经解剖学差异的遗传和分子基础.
主要方法:
- 利用了来自欧盟-AIMS LEAP队列的359名自闭症患者和279名对照 (6-30岁) 的数据.
- 使用FreeSurfer进行表面网格生成,以计算内在灰色物质的布线成本.
- 应用通用线性模型进行顶点对照组比较和基因表达分析 (艾伦人类大脑图谱),将发现与遗传因素联系起来.
主要成果:
- 发现了本质全球和本地电缆成本的显著群体差异.
- 这些差异主要位于中间和侧面的前额叶皮层,下部区域和左侧状结.
- 对以前与自闭症病因相关的基因进行了丰富的改变连接性的神经解剖学模式.
结论:
- 内在灰质的连接性为理解自闭症神经解剖学提供了一个新的镜头.
- 观察到的差异与潜在的基因组和分子机制有关,有助于分析自闭症异质性.
- 这些发现为未来关于自闭症分组和个性化方法的研究提供了潜在的目标.
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