人类病理中的表观遗传因素对lncRNAs的失调
Yanli Zhang1, Xiaocong Wang2, Chen Zhang3
1Central Laboratory, The First Hospital of Jilin University, Changchun, Jilin, China; Key Laboratory of Organ Regeneration and Transplantation, Ministry of Education, Changchun, Jilin 130021, China; Department of Echocardiography, The First Hospital of Jilin University, Changchun, Jilin, China.
Drug discovery today
|June 22, 2023
概括
长非编码RNAs (lncRNAs) 在癌症和自身免疫性疾病 (ADs) 等疾病中至关重要. 这篇评论探讨了表观遗传因素如何调节lncRNAs,为新的AD疗法提供了洞察力.
科学领域:
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
- 免疫学 免疫学 免疫学
背景情况:
- 长非编码RNA (lncRNAs) 在各种人类疾病的发病和进展中起着重要作用.
- lncRNAs的失调与癌症和自身免疫性疾病 (ADs) 等病理有关.
- 了解lncRNAs复杂的调节网络对于开发针对ADs的新型治疗策略至关重要.
研究的目的:
- 审查表观遗传因素在病理条件下调节lncRNAs的机制.
- 讨论 lncRNA表观遗传调节器在免疫反应和自身免疫性疾病中的参与.
- 在ADs中为lncRNAs的临床应用提供理论基础.
主要方法:
- 文献综述总结了 lncRNAs 的表观遗传调节.
- 分析由表观遗传因素引起的lncRNA失调,包括RNA结合蛋白和化学修饰.
- 讨论lncRNA表观遗传调节者的免疫反应和ADS中的作用.
主要成果:
- 表观遗传因素,如RNA结合蛋白,化学修饰 (例如,N6-甲基氨酸,DNA甲基化,基因组修饰),微RNA和替代拼接等,有助于lncRNA失调.
- lncRNA表观遗传调节器参与免疫反应和自身免疫性疾病的发病.
- 在疾病发展过程中,表观遗传因素和 lncRNAs之间存在复杂的相互作用.
结论:
- 对lncRNAs的表观遗传失调是自身免疫性疾病的发病的一个关键因素.
- 针对lncRNAs的表观遗传调节,为开发ADs的新疗法提供了一个有希望的途径.
- 对表观遗传因子-lncRNA网络的进一步研究将促进lncRNAs在治疗AD的临床应用.
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