由Streptococcus intermedius和Fusobacterium nucleatum引起的多肺炎:多感染的一个独特实体
Ruben Dyrhovden1, Tomas Mikal Eagan2,3, Øystein Fløtten2,3
1Department of Microbiology, Haukeland University Hospital, Bergen, Norway.
概括
口腔类型的膜感染,通常是由口腔细菌引起的,如Streptococcus intermedius和Fusobacterium nucleatum,是最常见的社区获得的膜感染. 牙感染是一个重要的危险因素,细菌通过血液传播.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
背景情况:
- 社区获得的多叶膜感染往往源于口腔微生物群,涉及选择性和无氧细菌.
- 这些口腔类型感染的流行病学,临床特征,病原和病因学研究不足.
- 一项前性的多中心队列研究,旨在全面描述口腔类型的肺部感染.
研究的目的:
- 提供口腔类型肺部感染的详细微生物学和临床特征.
- 增强对这些感染相关的病因和风险因素的理解.
- 为了确定参与病变发生的关键细菌物种.
主要方法:
- 一项为期2年的前性队列研究包括77名患有社区获得的肺部感染的患者.
- 63名患者 (82%) 患有口腔类型的胸腔感染,有系统的数据收集和牙科评估.
- 下一代测序用于微生物特征,比较了与牙病原性感染和脑的个人资料.
主要成果:
- 从口腔类型的肺部感染中,在89个物种中发现了267种细菌.
- 在所有确定的感染中,Streptococcus intermedius和/或Fusobacterium nucleatum是主要的.
- 观察到牙感染的高患病率和与牙病原性感染和脑的显著微生物相似性.
结论:
- 口腔型膜感染是社区获得的膜感染的主要形式.
- 细菌从牙焦点的血液传播是主要的疑似病因.
- 链球菌中介和Fusobacterium核可能是建立这些感染的关键病原体.
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