结直肠癌的性别差异:一个多中心的回顾性队列研究
Hyun Jin Joo1, Hyun Seok Lee2, Byung Ik Jang3
1Division of Gastroenterology, Department of Internal Medicine, Chung-Ang University Medical Center, Seoul, Republic of Korea.
Cancer reports (Hoboken, N.J.)
|June 22, 2023
概括
这项研究发现,韩国男女结肠直肠癌 (CRC) 存活率没有显著差异. 然而,男性更常被诊断为直肠癌,而女性更常患右结肠癌.
科学领域:
- 在瘤学瘤学.
- 基于性别的医学
- 胃肠病学 胃肠病学
背景情况:
- 结肠直肠癌 (CRC) 在发病率和特征上表现出性别特异性的差异.
- 了解这些差异对于制定有针对性的查,治疗和预防策略至关重要.
- 在韩国,很少有研究调查了性别特异性CRC差异.
研究的目的:
- 评估和比较韩国大肠直肠癌 (CRC) 的性别差异.
- 为了确定男性和女性之间的CRC呈现,特征和结果的潜在差异.
- 为制定性别定制的CRC管理方法提供信息.
主要方法:
- 在2012年至2013年期间诊断出3,114名CRC患者的回顾性多中心队列研究.
- 排除患有不确定的病期,先前/同时患有癌症或非上皮/in situ癌症的患者.
- 使用考克斯回归,卡普兰-梅尔和日志等级测试分析生存结果 (整体和无进展);使用千平方,费舍尔精确或t测试比较人口统计学和临床因素.
主要成果:
- 性别之间没有显著的开始年龄差异;男性通过健康检查更频繁地被诊断出无症状 (48.9%vs42.0%).
- 在男性中,直肠癌更为普遍 (38.8%对31.8%),而右结肠癌在女性中更为普遍 (31.4%对22.7%).
- 在34.4%的女性和23.3%的男性中观察到KRAS突变;整体和无进展生存率在两性之间是相似的.
结论:
- 在韩国人群中,结肠直肠癌 (CRC) 呈现和瘤位置存在性别差异.
- 生物学和社会行为因素可能有助于观察到的性别差异.
- 在CRC查,诊断和治疗中考虑性别特异性因素对于改善患者结果至关重要.
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