描述第一个全球mopox疫情:对全球监测数据的分析
Henry Laurenson-Schafer1, Nikola Sklenovská1, Ana Hoxha1
1Health Emergencies Programme, WHO, Geneva, Switzerland.
The Lancet. Global health
|June 22, 2023
概括
2022年的mopox (麻疹) 疫情主要是由男性之间的性接触引起的IIb类 MPXV驱动的. 在儿童,老年人,女性和免疫力低下的人群中,住院的风险更高.
科学领域:
- 流行病学 流行病学
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 2022年mopox (麻疹) 爆发标志着第一个大规模的全球事件,在非流行国家持续的社区传播.
- 世界卫生组织于2022年7月23日宣布疫情爆发为国际关注的公共卫生紧急情况.
研究的目的:
- 描述全球mopox疫情的流行病学特征.
- 分析与mopox住院相关的风险因素.
- 调查mpox病毒 (MPXV) 的遗传多样性和传播趋势.
主要方法:
- 对2022年1月1日至2023年1月29日确认的mopox病例的全球监测数据的分析.
- 使用病例报告表来报告人口统计,临床和暴露数据.
- 采用多变量混合效应二元物流回归来识别住院风险因素,并分析病毒遗传多样性的测序数据.
主要成果:
- 分析了超过82,000例病例,主要是由IIb类MPXV (系B.1) 引起的.
- 传播主要发生在通过性接触与男性发生性关系的男性中.
- 住院治疗更常见于5岁以下的儿童,65岁以上的成年人,女性和免疫力低下的人.
结论:
- 麻疹疫情是由 IIb 类 MPXV 驱动的,通过新的传播途径,主要是性接触.
- 全球监测对于监测疫情和告知公共卫生反应至关重要.
- 确定高风险群体对于有针对性的干预和预防策略至关重要.
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