相关实验视频

Updated: Sep 10, 2026

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Published on: February 17, 2022

化学抗原受体T细胞的早期和晚期毒性

Rebecca Epperly¹, Victoria M Giordani², Lekha Mikkilineni³

¹Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 1130, Memphis, TN 38105, USA.

Hematology/oncology clinics of North America

|June 22, 2023

概括

化学抗原受体 (CAR) T细胞疗法在治疗癌症方面表现有前途. 本综述更新了CAR T细胞毒性,重点关注新出现的问题和超出细胞因子释放综合征和神经毒性之外的长期影响.

科学领域:

免疫治疗是一种免疫疗法.
在瘤学瘤学.
细胞疗法细胞疗法

背景情况:

化学抗原受体 (CAR) T细胞治疗是一种快速发展的癌症治疗方法.
针对CD19的CAR T细胞疗法已经确定了细胞因子释放综合征和神经毒性作为主要急性毒性.
管理这些毒性对于成功的临床整合至关重要.

研究的目的:

提供与CAR-T细胞相关的毒性的最新概述.
突出影响各种器官系统的新出现的急性毒性.
讨论延迟毒性和CAR T细胞疗法的晚期影响的考虑因素.

主要方法:

对当前CAR T细胞疗法毒性的文献综述.
对新出现的不良事件和长期后果的分析.
综合临床经验和专家建议.

主要成果:

除了细胞因子释放综合征和神经毒性之外,其他急性毒性正在出现.
延迟的毒性和延迟的效果需要持续的监测和管理.
对整个毒性谱的全面了解至关重要.

结论:

有效地识别和管理CAR T细胞毒性对于患者安全和治疗成功至关重要.
需要持续的研究和临床警,以应对CAR T细胞相关不良事件的不断变化的情景.
需要采取积极的策略,以减轻与CAR T细胞疗法相关的急性和长期毒性.

关键词:

骨髓功能障碍骨髓功能障碍骨髓功能障碍化学抗原受体T细胞.细胞因子释放综合征细胞因子释放综合征细胞衰竭症 (cytopenia) 是一个严重的疾病.免疫效应细胞相关的神经毒性综合征传染性并发症感染性并发症

更多相关视频

Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model

Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model

Published on: February 10, 2023

Droplet-based Cytotoxicity Assay to Assess Chimeric Antigen Receptor T cells at the Single-cell Level

Droplet-based Cytotoxicity Assay to Assess Chimeric Antigen Receptor T cells at the Single-cell Level

Published on: March 14, 2025

相关概念视频

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...