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对抗SARS-CoV-2疫苗的过敏反应:基因细胞对辅助剂的反应性
Patrizia Pignatti1, Giuseppe Alvise Ramirez2, Marco Russo3
1Allergy and Immunology Unit, Istituti Clinici Scientifici Maugeri IRCCS Pavia, 27100 Pavia, Italy.
Vaccine
|June 22, 2023
概括
基细胞激活测试 (BAT) 显示出诊断对COVID-19疫苗过敏的可能性,特别是延迟反应. 在这些疫苗过敏病例中,DMG-PEG 2000是关键的过敏原.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏 诊断 过敏 诊断
背景情况:
- 基细胞激活试验 (BAT) 是对过敏反应的诊断工具.
- 它在诊断对严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 疫苗过敏的有用性,特别是延迟反应,尚未得到充分证实.
- 对SARS-CoV-2疫苗的过敏反应可能涉及各种机制,并急性或延迟表现.
研究的目的:
- 调查BAT在诊断对抗SARS-CoV-2疫苗过敏性的作用.
- 为了确定与过敏反应相关的特定疫苗成分.
- 在疑似过敏对照组的患者中比较BAT结果.
主要方法:
- 89名疑似对抗SARS-CoV-2疫苗过敏的患者接受了常见辅助剂 (Macrogol 3350,DMG-PEG 2000,PEG 20000,polysorbate-80,trometamol) 的BAT.
- 结果与156名接受疫苗前BAT的受试者进行了比较.
- 进行了统计分析,以将BAT阳性与反应发作,分辨率和特定辅助剂相关联.
主要成果:
- 一个积极的BAT与过敏反应的延迟发作和解决相关.
- 在患者和对照组中,DMG-PEG 2000比其他辅助剂更频繁地引起了积极的BAT.
- 与未接种疫苗的受试者相比,DMG-PEG 2000的反应性在接种疫苗的受试者中明显高 (35%),与mRNA-1273疫苗接种相关.
结论:
- 针对DMG-PEG2000的BAT可以作为对SARS-CoV-2疫苗延迟过敏反应的诊断工具.
- 自然免疫力可能在基细胞激活中发挥作用.
- 最佳技术 (BAT) 补充了与疫苗相关的过敏常规过敏诊断.
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