视网醇摄入量与ISX rs5755368多态性在结直肠癌风险中的相互作用:一项针对韩国人口的病例对照研究
Anh Quynh Bui1, Madhawa Gunathilake2, Jeonghee Lee2
1Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang-si, Gyeonggi-do, South Korea.
Scientific reports
|June 22, 2023
概括
饮食中的雷丁醇摄入量与降低结直肠癌 (CRC) 风险有关. 这种保护作用在具有ISX rs5755368多态的AA基因型的个体中显著增强.
科学领域:
- 营养流行病学 营养流行病学
- 遗传流行病学遗传流行病学
- 癌症研究 癌症研究
背景情况:
- 饮食因素在癌症的发展中起着至关重要的作用.
- 乙醇是维生素A的一种形式,已被研究其在预防癌症方面的潜在作用.
- 遗传变异可能会影响个体对饮食成分的反应.
研究的目的:
- 为了调查饮食中的视网醇消费与结肠直肠癌 (CRC) 风险之间的关联.
- 检查ISX rs5755368基因型是否改变了饮食中的视网醇与CRC风险之间的关系.
主要方法:
- 一项涉及923名CRC患者和1846名对照者的病例控制研究.
- 通过半定量食品频率调查问卷评估的饮食中的视网醇摄入量.
- 使用Illumina MEGA扩展阵列进行ISX rs5755368的基因型定型;通过后勤回归进行统计分析.
主要成果:
- 雷丁醇摄入量与CRC风险呈反向关联 (OR=0.49).
- 与G等位基因相比,AA基因型与较低的CRC风险有关 (OR=0.76).
- 摄入量最高的视网醇和AA基因型的个体表现出显著降低的CRC风险 (OR=0.32;P相互作用=0.026).
结论:
- 饮食中摄入的网醇可以起到预防CRC的保护作用.
- 视网醇对CRC的保护作用在具有ISX rs5755368.8的同卵性AA基因型的个体中得到了增强.
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