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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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在复发性复发性多发性硬化症患者中,微观结构变化先于抑郁症.

Frank Riemer1,2, Ellen Skorve3,4, Ofer Pasternak5,6

  • 1Mohn Medical Imaging and Visualization Centre (MMIV), Department of Radiology, Haukeland University Hospital, 5021, Bergen, Norway. f.riemer@web.de.

Communications medicine
|June 22, 2023
PubMed
概括
此摘要是机器生成的。

多发性硬化症 (MS) 早期的大脑变化与后来的抑郁症有关. 在皮层下MS病变中,较高的自由水预测了抑郁症症状,突出了关键的关系.

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科学领域:

  • 神经成像是一种神经成像.
  • 神经学 神经学
  • 精神病学是一个精神病学.

背景情况:

  • 多发性硬化症 (MS) 的脑病变会导致认知和情绪障碍.
  • 在MS患者中,皮下体积的早期微观结构变化可能会先于情绪功能障碍.

研究的目的:

  • 研究早期皮下微观结构变化与复发缓解多发性硬化症的认知/情绪功能之间的时间关系.
  • 探索早期的MRI衍生的指标如何预测MS中以后的情绪状态.

主要方法:

  • 在46名复发性复发性多发性硬化症患者的长度体内MRI (3年).
  • 使用自由水分数 (FW-MRI) 评估下皮层微结构变化.
  • 相关的FW-MRI指标与使用预测建模的医院焦虑和抑郁量表得分.

主要成果:

  • 皮下结构的基线自由水估计与2年随访时的抑郁症得分相关.
  • 塔拉木斯FW-MRI显示,在预测抑郁症方面,效果大小最大.
  • 在高抑郁和低抑郁组之间观察到高和桃体/海马体的显著FW-MRI差异.

结论:

  • 在早期多发性硬化症下皮层结构中增加的自由水与后来的抑郁症状有关.
  • 这一发现表明,FW-MRI可以识别患MS抑郁症的风险人群.