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在原发性肺癌和肺转移中诊断胃肠道标志物

Karina Malmros¹, Andreas Lindholm², Halla Vidarsdottir^1,3

¹Division of Pathology, Department of Clinical Sciences Lund, Lund University, SE-221 00, Lund, Sweden.

Virchows Archiv : an international journal of pathology

|June 22, 2023

概括

从胃肠道 (GI) 转移中区分原发性肺癌是具有挑战性的. 虽然CDH17,GPA33和SATB2表现有前途,但没有单一或组合的免疫组织化学标志物能够确定分离这些瘤.

科学领域:

在瘤学瘤学.
病理学病理学病理学
胃肠病学胃肠病学

背景情况:

精确的肺部瘤组织病理学诊断对于有效的治疗计划至关重要.
从胃肠道 (GI) 途径转移中区分初级肺腺癌是一个重大的诊断挑战.

研究的目的:

为了比较各种免疫组织化学标志物的诊断效用,以区分原发性肺癌与肠道转移.
评估新型标记物,如CDH17,GPA33,MUC2,MUC6,SATB2和SMAD4,以及已建立的标记物,如CDX2,CK20,CK7和TTF-1.

主要方法:

分析了来自629种原发性肺癌和422种胃肠道起源的肺上皮转移的组织微阵列.
对CDH17,GPA33,MUC2,MUC6,SATB2,SMAD4,CDX2,CK20,CK7和TTF-1表达的免疫组织化学评估.

主要成果:

GPA33,CDX2和CDH17对GI原产地 (98-100%) 呈现出高灵敏度.
SATB2和CK20表现出更高的特异性,在初级肺腺癌中表达有限.
没有单个标志物或组合可靠地区分所有初级肺癌与肠道转移,包括具有挑战性的子组.

结论:

CDH17,GPA33和SATB2是识别肠道转移的CDX2和CK20的潜在替代品.
尽管有前景的标记物,但目前还缺乏一个明确的免疫组织化学面板,可以明确区分原发性肺癌与肠道转移.

关键词:

A3333 A3333 A333 A333 A333 A333 A333 A333 A333 A333 A333 A333 A333 A333 A333 A333 A333 A333 A333 A333 A333 A333 A333 A CDX2 CDX2 CDX2 CDX2 CDX2 CDX2 CDX2 CDX2 CDX2 CDX2 CDX2 20克朗 (约合人民币) 的时间.卡德林 17 种 17 种免疫组织化学免疫组织化学在MUC2中,MUC2是MUC2.在SATB2中,SATB2是SATB2的第二种类型.

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