作为一种有效的治疗急性术后疼痛后脊髓手术没有重大副作用的普雷加巴林:前性,随机对照,双盲试验的协议
Ki-Hoon Park1, Nam-Su Chung1, Hee-Woong Chung1
1Department of Orthopaedic Surgery, Ajou University School of Medicine, Suwon, South Korea.
Trials
|June 22, 2023
概括
这项研究调查了在脊髓手术后管理术后疼痛的最佳普雷加巴林剂量. 研究结果将指导有效的疼痛管理,并尽量减少患者的副作用.
科学领域:
- 麻醉学 麻醉学
- 神经外科 神经外科
- 药理学 药理学是指药理学的学科.
背景情况:
- 术后疼痛显著影响康复,并可能导致诸如肺部问题和压力等并发症.
- 在脊柱手术后,有效的疼痛管理至关重要.
- gabapentinoids 是常见的止痛药,但它们的疗效和副作用取决于剂量.
研究的目的:
- 为了评估不同术后佩加巴林剂量用于脊柱手术疼痛的疗效和安全性.
- 为了确定术后疼痛管理的最佳普雷加巴林剂量.
- 评估pregabalin对疼痛评分和止痛药需求的影响.
主要方法:
- 一项前性,随机,双盲,安慰剂控制的研究,共132名参与者.
- 四组:安慰剂,普雷加巴林25毫克,50毫克和75毫克,在手术前和手术后服用72小时.
- 主要结局:视觉模拟尺度疼痛评分,患者控制的止痛疗法 (PCA) 使用,以及救援止痛疗法的频率.
主要成果:
- 这项研究旨在提供关于普雷加巴林最佳剂量的证据.
- 它将在不同剂量的普雷加巴林中比较疼痛评分和止痛药消耗.
- 将分析恶心,吐,镇静和头等副作用的发生率.
结论:
- 普雷加巴林提供了镇痛效果和阿片类药物缓解效果,而没有与NSAID相关的非联合风险.
- gabapentinoids 表明恶心,吐和的风险降低.
- 这项研究将建立基于证据的普雷加巴林剂量用于术后脊柱手术疼痛.
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