对低HER2乳腺癌的治疗选择的审查以及拟议的治疗序列算法
Arya Mariam Roy1, Vasanthan Muthusamy Kumarasamy2, Ajay Dhakal3
1Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.
Cancer
|June 23, 2023
概括
人类表皮生长因子受体2 (HER2) -低乳腺癌 (BC) 的新分类提供了一个可向的生物标志物. 特拉斯图祖马布德鲁克斯泰康显示了生存益处,影响了对HER2-低BC的治疗算法.
科学领域:
- 在瘤学瘤学.
- 生物标志物发现发现
- 临床治疗学 临床治疗学
背景情况:
- 乳腺癌 (BC) 中人类表皮生长因子受体2 (HER2) 状态的定义已扩大,包括HER2低表达 (IHC 1+或IHC 2+没有基因放大).
- 低HER2的BC代表了激素受体阳性和三阴性乳腺癌的很大一部分,约占病例的50%.
- 作为可向生物标志物的低HER2的出现对治疗策略有深远的影响.
研究的目的:
- 列举 HER2 低水平乳腺癌的治疗选择.
- 根据当前的临床证据,提出 HER2-low BC 的治疗测序算法.
- 根据新的HER2-低BC数据,需要重新考虑治疗算法.
主要方法:
- 关于治疗HER2-低BC的治疗剂的当前临床证据的审查.
- 对激素受体阳性和激素受体阴性HER2-低BC的可用治疗选择的列表.
- 开发一个拟议的治疗序列算法.
主要成果:
- 抗HER2抗体-药物结合物trastuzumab deruxtecan在预先治疗的转移性HER2-低BC中显示出显著的生存益处.
- 大约一半的激素受体阳性和三阴性乳腺癌呈现HER2-低表达.
- 现有的治疗药物在荷尔蒙受体阳性与荷尔蒙受体阴性HER2-低BC中显示出差异性疗效.
结论:
- 低HER2状态是乳腺癌治疗中的关键,可向的生物标志物.
- 特拉斯图祖马布德鲁克斯泰坎在预先治疗的转移性HER2-低BC患者中提供了显著的生存优势.
- 对于HER2-低BC的治疗顺序需要达成共识,这篇文章提出了一个基于证据的算法.
关键词:
低HER2水平的乳腺癌.在 PARP 抑制剂.在阿尔佩里斯比利斯,它是不可思议的.这是Everolimus.荷尔蒙受体阴性HER2-低激素受体阳性HER2-低的萨基图祖马布 (Sacituzumab) govitecan可以使用.特拉斯图祖马布可以脱.更多相关视频
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