肠道病毒组的变化与2型糖尿病和糖尿病病有关
Gang Fan1, Feng Cao2, Tingting Kuang1
1State Key Laboratory of Southwestern Chinese Medicine Resources, School of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Gut microbes
|June 23, 2023
概括
肠道病毒组,包括像菌体这样的病毒,在2型糖尿病 (T2D) 和糖尿病病 (DN) 中发生变化. 减少的病毒多样性和破坏的病毒-细菌相互作用表明T2D和DN的潜在诊断标记.
科学领域:
- 微生物学 微生物学
- 病毒学 病毒学
- 转基因组学是指转基因组学.
背景情况:
- 肠道微生物组的改变与2型糖尿病 (T2D) 和其并发症有关.
- 肠道病毒在T2D和糖尿病病 (DN) 中的特定作用仍然在很大程度上未被探索.
研究的目的:
- 描述T2D和DN的肠道病毒组变化.
- 研究肠道病毒和细菌标记物的诊断潜力.
主要方法:
- 便病毒样颗粒的元基因组测序.
- 对病毒丰富性,多样性和物种丰富性的比较分析.
- 评估病毒功能和病毒-细菌相互作用.
主要成果:
- 与对照组相比,T2D和DN受试者表现出明显较低的病毒丰富性和多样性.
- 特定的病毒物种,包括各种菌体,在T2D和DN中显著改变.
- 病毒功能,如菌素溶解,减少,病毒-细菌相互作用被破坏.
- 结合病毒和细菌标志物显示T2D和DN的高诊断性能 (AUC>98%).
结论:
- T2D和DN与肠道病毒多样性的减少,病毒物种的改变,病毒功能的减少和病毒-细菌相关性的破坏有关.
- 肠道病毒组为开发T2D和DN的新型诊断生物标志物提供了一个有希望的途径.
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