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Updated: Jun 23, 2026

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
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Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

Published on: April 11, 2018

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在膝盖建模和仿真中的可复制性:学术,行业和监管视角

Carl W Imhauser1, Andrew P Baumann2, Xiangyi Cheryl Liu3

  • 1Department of Biomechanics, Hospital for Special Surgery, New York, New York, USA.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society
|June 23, 2023
PubMed
概括

在膝盖生物力学建模中,可重复性至关重要. 利益相关者认为,数据共享和明确的标准是推动计算膝盖M&S和临床前评估的关键.

关键词:
可信度 可信度 可信度膝盖 膝盖 膝盖 在建模建模是什么意思监管部门的监管机构.可复制性的可复制性模拟模拟是指一个模拟模拟.

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Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions01:15

Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions

PK–PD modeling has significantly influenced FDA regulatory decisions, particularly drug approval, dosage optimization, and labeling. These models integrate pharmacokinetics (PK) and pharmacodynamics (PD) to predict drug behavior and effects, aiding in optimizing dosing regimens and enhancing the probability of clinical trial success.One notable example is Nesiritide (Natrecor®), a recombinant human brain natriuretic peptide for treating acute decompensated congestive heart failure (CHF).