将关节高移动性置于背景:特征,疾病和综合征
Silvia Morlino1, Marco Castori1
1Division of Medical Genetics, Fondazione IRCCS-Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
British medical bulletin
|June 23, 2023
概括
关节高运动 (JHM) 和相关的肌肉骨疼痛是常见的. 本综述阐明了超运动谱系障碍 (HSD) 和埃勒斯-丹洛斯综合征 (EDS),强调了诊断方面的挑战和未来的研究需求.
科学领域:
- 结合组织疾病 结合组织疾病
- 肌肉骨健康 肌肉骨健康
- 遗传学和罕见疾病.
背景情况:
- 关节高移动性 (JHM) 是一种普遍的身体特征,通常与肌肉骨 (MSK) 疼痛有关.
- 超移动性谱系障碍 (HSD) 是当JHM和MSK疼痛缺乏替代诊断时被诊断出来的.
- 埃勒斯-丹洛斯综合征 (EDS) 是一种罕见的遗传性结缔组织疾病,具有JHM和多种表现;2017年分类详细介绍了13种亚型.
研究的目的:
- 定义和介绍JHM的流行病学,评估和模式.
- 为了说明2017年EDS分类的性质和超级移动性相关条件的"频谱"概念.
- 讨论有关HSD和超移动EDS (HEDS) 的现有局限性和争议.
主要方法:
- 文献综述侧重于关键论点,优先考虑在2017年EDS分类后发表的论文.
- 综合关于JHM定义,流行病学和评估工具的信息.
- 对现有的文献进行分析,以确定超流动性分类中的共识和争议领域.
主要成果:
- 2017年EDS分类确定了13种亚型,其中超移动EDS (HEDS) 目前缺乏确认性诊断测试.
- 介绍了超移动性障碍中的"频谱"概念,以及JHM和HSD的定义和流行病学数据.
- 目前在HSD和HEDS的分类和诊断方面存在的局限性和分歧被强调.
结论:
- 阐明JHM相关疼痛的病理生理学需要对相关的类表现进行并行调查.
- 未来的研究应该解决JHM,EDS和相关疾病的分类,鼻科,诊断和管理方面的挑战.
- 审查强调需要继续研究基因,疼痛和超移动性综合征的系统特征的复杂相互作用.
相关概念视频
Functional Classification of Joints
4.2K
Functional Classification of Joints
The functional classification of joints is determined by the amount of mobility between the adjacent bones. Joints are functionally classified as a synarthrosis or immobile joint, an amphiarthrosis or slightly moveable joint, or as a diarthrosis, a freely moveable joint. Fibrous and cartilaginous joints can be functionally classified as either synarthroses or amphiarthroses, whereas all synovial joints are classified as diarthroses.
Synarthrosis
An...
The functional classification of joints is determined by the amount of mobility between the adjacent bones. Joints are functionally classified as a synarthrosis or immobile joint, an amphiarthrosis or slightly moveable joint, or as a diarthrosis, a freely moveable joint. Fibrous and cartilaginous joints can be functionally classified as either synarthroses or amphiarthroses, whereas all synovial joints are classified as diarthroses.
Synarthrosis
An...
4.2K
Disorders of the Skeletal Muscle
999
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
999
Joints
33.0K
Joints, also called articulations or articular surfaces, are points at which ligaments or other tissues connect adjacent bones. Joints permit movement and stability, and can be classified based on their structure or function.
Structural joint classifications are based on the material that makes up the joint as well as whether or not the joint contains a space between the bones. Joints are structurally classified as fibrous, cartilaginous, or synovial.
Fibrous Joints Are Immovable
The bones of a...
Structural joint classifications are based on the material that makes up the joint as well as whether or not the joint contains a space between the bones. Joints are structurally classified as fibrous, cartilaginous, or synovial.
Fibrous Joints Are Immovable
The bones of a...
33.0K
Structural Joints: Synovial Joints
3.7K
Synovial joints are the most common type of joint in the body. A key structural characteristic for a synovial joint is the presence of a joint cavity. This fluid-filled space is where the articulating surfaces of the bones contact each other. Also, unlike fibrous or cartilaginous joints, the articulating bone surfaces at a synovial joint are not directly connected to each other with fibrous connective tissue or cartilage. This gives the bones of a synovial joint the ability to move smoothly...
3.7K
Development of the Limb Synovial Joints
1.4K
Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
1.4K
Ankle Joint
1.6K
The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...
1.6K


