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渐进的髓损伤暗示了血管内大B细胞淋巴瘤

Sho Kitahara¹, Masato Kanazawa¹, Manabu Natsumeda²

¹Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan.

European journal of neurology

|June 23, 2023

概括

血管内大B细胞淋巴瘤 (IVLBCL) 中的脊髓损伤通常具有慢性进展,与大脑损伤不同. 骨的病变是早期IVLBCL诊断的关键指标.

科学领域:

神经学神经学
在瘤学瘤学.
血液学血液学血液学

背景情况:

血管内大B细胞淋巴瘤 (IVLBCL) 是一种影响中枢神经系统的罕见疾病.
脊髓病变发生在40%的IVLBCL中枢神经系统病例中.
在IVLBCL中脊髓干涉的临床特征尚未明确,这可能会延迟诊断.

研究的目的:

为了澄清IVLBCL患者脊髓病变的临床特征.
在IVLBCL中区分脊髓干涉与大脑干涉.
改善IVLBCL脊髓损伤的早期诊断和治疗策略.

主要方法:

追溯搜索IVLBCL患者 (2010-2020) 的医疗记录.
包括标准:神经症状,病理确认的IVLBCL,没有非神经症状.
脊髓与大脑参与的临床特征的评估.

主要成果:

确定了16名IVLBCL患者:6名脊柱干涉 (脊柱类型),10名脑干涉 (脑类型).
脊髓类型主要表现为慢性 (4/6) 或亚急性 (2/6) 进展.
脊髓类型的急性发病率 (0%) 和突然发病率 (0%) 与大脑类型相比,脊髓类型的急性发病率明显低 (分别为80%和50%).
所有的脊髓病变都位于脊髓中.

结论:

在IVLBCL中,脊髓干涉具有典型的慢性渐进过程,与大脑干涉不同.
髓的病变高度暗示IVLBCL.
识别这些特征有助于更早,更准确地诊断和治疗IVLBCL.

关键词:

体中枢的体 (conus medullaris) 是一个淋巴瘤淋巴瘤是什么骨髓病变是一种骨髓病变.神经学的表现神经系统的表现.

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