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败血症使行为安非他胺反应敏感,同时在结和穿孔模型中诱导炎症和神经营养脆弱性
Samira S Valvassori1, Taise Possamai-Della1, Jorge M Aguiar-Geraldo1
1Translational Psychiatry Laboratory, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma, Brazil.
The European journal of neuroscience
|June 23, 2023
概括
败血症使老鼠对m-安非他胺敏感,增加行为反应和神经炎症. 这项研究揭示了毒引起的脑功能和神经营养因子在胺暴露后的脆弱性.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 败血症研究 败血症研究
背景情况:
- 败血症可能导致长期的神经复杂症.
- 败血症和精神兴奋剂 (如m-安非他胺) 之间的相互作用尚未完全理解.
- 研究这些相互作用对于理解败血症后的行为变化至关重要.
研究的目的:
- 为了确定败血症是否使行为和生化反应对m-anfetamine敏感.
- 为了检查败血症和m-安非他胺对炎症标志物,神经营养因子和老鼠大脑中的特定蛋白质水平的影响.
主要方法:
- 威斯塔尔老鼠接受了结和穿孔 (CLP) 诱导败血症.
- 动物在CLP后接受不同剂量的盐水或m-安非他胺.
- 评估了运动行为,并测量了细胞因子 (IL-1β,IL-6,IL-10,TNF-α),DARPP-32,NCS-1和神经营养因子 (BDNF,NGF,GDNF) 的水平.
主要成果:
- 与对照组相比,败血症加上m-anfetamine显著增加了运动,探索和风险行为.
- 败血症导致白血素水平升高,而白血素水平被m-安非他胺进一步放大.
- M-安非他胺以剂量依赖的方式调节神经营养因子,并增加了DARPP-32和NCS-1水平在败血性大鼠的特定大脑区域.
结论:
- 败血症使得对m-安非他命的行为反应敏感.
- 结结和刺穿模型表明,毒症后的炎症和神经变脆弱性.
- 这些发现凸显了败血症的复杂神经生物学后果及其与兴奋剂药物的相互作用.
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