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Updated: Jul 26, 2025

A Method to Study de novo Formation of Chromatin Domains
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A Method to Study de novo Formation of Chromatin Domains

Published on: August 23, 2019

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广泛的H3K4me3域名:维持细胞身份及其在超强增强器劫持中的含义

Daniel Kent1, Letizia Marchetti1, Aneta Mikulasova1

  • 1Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

BioEssays : news and reviews in molecular, cellular and developmental biology
|June 23, 2023
PubMed
概括

广泛的H3K4me3域 (H3K4me3-BDs) 标志着健康细胞中的基因表达,但是在癌症中的癌基因上发现的. 这种与超级增强剂 (SE) 相关的癌症特征为SE驱动的癌症提供了潜在的治疗点.

关键词:
H3K4me3是什么意思 H3K4me3是什么意思这是一个超级增强器.转移转移的转移情况

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Histone Modification02:32

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
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Spreading of Chromatin Modifications

The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
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Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
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