长非编码RNA作为非小细胞肺癌的潜在治疗点 (综述)
Peiyu Tang1, Dejuan Sun1, Wei Xu2
1Wuya College of Innovation, Key Laboratory of Structure‑Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, P.R. China.
International journal of molecular medicine
|June 23, 2023
概括
长非编码RNAs (lncRNAs) 与非小细胞肺癌 (NSCLC) 的发展和耐药性有关. 本综述探讨了ncRNAs作为NSCLC的潜在生物标志物和治疗点.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 非小细胞肺癌 (NSCLC) 由于高发病率和死亡率,给全球健康带来了重大挑战.
- 长非编码RNAs (lncRNAs) 越来越多地被认为对癌症的发展和进展起作用.
- lncRNAs影响NSCLC患者的耐药性和辐射敏感性.
研究的目的:
- 在NSCLC的背景下审查和分类lncRNAs的功能.
- 总结 lncRNAs 在 NSCLC 病原和治疗反应中的潜在作用.
- 突出 lncRNAs作为潜在的诊断生物标记物和NSCLC的治疗点.
主要方法:
- 文献综述和对NSCLC中lncRNAs现有研究的综合.
- 基于 lncRNAs 在癌症中的作用的功能分类.
- 讨论受 lncRNAs 影响的生理方面,包括扩散,入侵和耐药性.
主要成果:
- lncRNA与NSCLC的发生和进展密切相关.
- lncRNAs在NSCLC中对药物耐药性和辐射敏感性的发展中发挥着作用.
- lncRNAs表现出功能特征,组织特异性和性别特异性.
结论:
- lncRNAs代表了NSCLC诊断的有希望的新生物标志物.
- lncRNAs有可能成为NSCLC治疗的治疗点.
- 本综述提供了关于lncRNAs在治疗NSCLC中的实用性的观点.
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