神经性眼睛干燥与内内注射抗VEGF药物相关
Shu-Hua Lin1,2, Yu-Hui Fang3, Fa-Li Jia2
1Department of Ophthalmology, Fuyang People's Hospital of Anhui Medical University, Fuyang, Anhui, China.
European journal of ophthalmology
|June 23, 2023
概括
神经性干眼可能在静脉内拉尼比祖马布注射后发展,特别是在之前接受过眼科手术的患者中. 这种情况可能是由于药物的透性增加和影响神经修复的角膜变化造成的.
科学领域:
- 眼科医生 眼科 眼科
- 角质科学 角质科学
- 神经眼科神经眼科
背景情况:
- 静脉内拉尼比祖马布注射 (IVR) 用于治疗各种视网膜疾病.
- 之前的眼科手术,包括白内障发泡,眼内透镜 (IOL) 植入,Nd:YAG激光后部囊切除,以及女性秒激光辅助激光 in situ 角膜切除 (FS-LASIK),可以改变眼睛的结构.
- 神经性干眼 (NDE) 的特点是角膜敏感性降低和眼的产生.
研究的目的:
- 报告一种神经性干眼 (NDE) 病例,该病例是在静脉内拉尼比祖马布注射 (IVR) 后出现的.
主要方法:
- 一个71岁的妇女的案例研究,她有多次眼睛手术的历史.
- 该患者因被诊断为视网膜动脉瘤而接受了静脉内射拉尼比祖马布注射.
- 眼睛表面的评估包括膜破裂时间 (TBUT),希尔默测试,角膜光素染色 (CFS) 和角膜触摸值测量.
主要成果:
- 患者在第二次IVR后出现了严重的干眼症状,包括干燥,光恐惧,刺激和视力模糊.
- 诊断测试显示,TBUT (3秒) 和希尔默测试值 (2毫米/5分钟) 显著降低.
- 角膜检查显示了扩散的皮带染色 (>50%的角膜) 和角膜边缘的不规则染色,角膜触摸值降低.
结论:
- 之前的眼科手术可能会使患者在IVR后倾向于NDE.
- 增加的药物透性和角膜 stromal 稀薄,可能被抗VEGF 药物加剧,可以破坏角膜下皮质神经修复机制.
- 这种干扰可以导致神经性干眼的发展.
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