新发性心房的预测:HARMS2-AF风险评分
Louise Segan1,2,3, Rodrigo Canovas2,4,5, Shane Nanayakkara1,2,6
1Department of Cardiology, The Alfred Hospital, 55 Commercial Road, Melbourne, VIC 3004, Australia.
European heart journal
|June 23, 2023
概括
一个新的生活方式风险评分,HARMS2-AF,有效地识别高风险的人心房动 (AF). 这一分数有助于对人口进行查和管理AF预防的可修改风险因素.
科学领域:
- 心脏病学 心脏病学
- 流行病学 流行病学
- 预防医学 预防医学
背景情况:
- 生活方式因素是管理心房动 (AF) 的关键,但可以修改的目标.
- 个人生活方式风险因素对AF发展的具体影响尚不清楚.
- 开发一种工具来量化AF的生活方式风险对于有针对性的干预措施至关重要.
研究的目的:
- 开发和验证一种新的心房动 (AF) 的生活方式风险评分.
- 在一般人群中识别有发展AF风险的个体.
- 评估与现有模型相比,新得分的预测性能.
主要方法:
- 利用了大型前性队列:英国生物银行 (UKB) 和弗拉明汉心脏研究 (FHS).
- 采用Cox比例危险回归来确定独立的AF预测因素.
- 开发并使用UKB数据和FHS数据对HARMS2-AF评分进行外部验证.
主要成果:
- 高血压,年龄,BMI,男性性别,睡眠呼吸暂停,吸烟和饮酒是显著的AF预测因素 (P<0.001).
- 哈姆斯2-AF得分显示出强大的预测性表现 (UKB AUC 0.782,FHS AUC 0.757).
- 较高的HARMS2-AF得分与显著增加的AF风险相关,优于其他既定的风险模型.
结论:
- 哈姆斯2-AF评分是有效的工具,用于识别有心房动风险的个体.
- 这种新的得分可以帮助在人口层面对AF进行查.
- 哈姆斯2-AF评分为AF预防提供了可修改的生活方式风险因素的有针对性的管理.
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