身体质量指数的关联及其与事件糖尿病的变化
Ryusei Ohno1, Hidehiro Kaneko1,2, Kensuke Ueno1,3
1The Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
The Journal of clinical endocrinology and metabolism
|June 23, 2023
概括
体重指数 (BMI) 超过20-21公斤/平方米显著增加糖尿病 (DM) 的风险. 保持稳定或降低的BMI对于预防DM至关重要,特别是对于正常体重,超重和肥胖的人来说.
科学领域:
- 代谢健康和疾病预防
- 慢性疾病的流行病学.
背景情况:
- 关于糖尿病 (DM) 发展的体重指数 (BMI) 值的数据有限.
- 体重指数变化与随后的DM风险之间的关系需要进一步澄清.
研究的目的:
- 调查身体质量指数 (BMI) 和发生糖尿病 (DM) 之间的关联.
- 澄清BMI变化对发展DM的风险的影响.
主要方法:
- 使用JMDC索赔数据库 (2005-2021) 进行的回顾性观察队列研究.
- 包括3400303个没有先前使用DM或降血糖药物的个人.
- 参与者按BMI (体重不足,正常,超重,肥胖) 和BMI变化 (≤-5.0%, -5.0%至+5.0%, ≥+5.0%) 分类.
主要成果:
- 当BMI超过20-21kg/m2时,糖尿病 (DM) 的风险急剧增加.
- 体重指数增加≥5.0%增加了DM风险 (相对风险:1.33,95% CI 1.31-1.36).
- 体重指数下降≥5.0%可以降低DM风险 (相对风险:0.82,95% CI 0.80-0.84).
结论:
- 研究结果为最佳的体重管理策略提供了洞察力,以预防DM.
- 降低正常体重,超重和肥胖个体的BMI降低了DM风险.
- 体重不足的人在BMI下降时经历了DM风险增加.
更多相关视频
08:13Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
68.8K
07:44Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass
Published on: July 14, 2023
1.2K
相关概念视频
Diabetes: Symptoms, Diagnosis, and Complications
605
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
605
Diabetes Mellitus: Type 2 and Gestational
2.6K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.6K
Obesity
549
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
549
Pathophysiology of Diabetes
1.0K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.0K
Diabetes Mellitus: Overview and Type I Subtype
2.8K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.8K
Carbohydrate Metabolism
11.3K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.3K
