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动脉硬与癌症死亡率有关:来自Kailuan研究的洞察力

Jiatian Li¹, Tesfaldet Habtemariam Hidru¹, Yajuan Lin¹

¹Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University, Dalian, China.

Cancer medicine

|June 23, 2023

概括

增加的动脉硬度,以腕脉冲波速度 (baPWV) 衡量,与癌症患者 (ACMC) 死亡因任何原因的风险更高有关. 这种风险在男性和年轻的癌症患者中尤为明显.

科学领域:

心血管健康心血管健康
在瘤学瘤学.
血管生物学血管生物学

背景情况:

关于动脉狭窄与癌症患者全因死亡率 (ACMC) 之间的联系的证据有限.
动脉硬,通过手臂脚脉冲波速度 (baPWV) 评估,是血管健康的标志物.
这项研究旨在探索baPWV和ACMC之间的关联.

研究的目的:

调查 baPWV 测量的动脉硬度与癌症患者全因死亡风险之间的关系.
确定 baPWV 表示的动脉功能和结构是否预测癌症患者的死亡率.

主要方法:

一组43,943名中国成年人接受了baPWV检查.
考克斯的比例危险模型被用来分析baPWV值和ACMC之间的关联.
随访持续时间平均为3.81±2.50年,553例癌症病例中记录了157例死亡.

主要成果:

与具有理想血管功能的患者相比,baPWV ≥18 m/s的患者表现出较高的ACMC风险.
在baPWV≥18 m/s的动脉硬程度和ACMC (HR 2.72;p < 0.001) 之间发现了显著的关联.
在总体队列中,baPWV的每一次1-SD增加与ACMC风险增加相关 (HR 1.20; p < 0.05),男性和患者 ≤60岁.

结论:

较高的baPWV标志着动脉硬度升高,与癌症患者全因死亡风险增加显著相关.
与高baPWV (≥18 m/s) 相关的ACMC风险增加在男性和60岁或更年轻的个人中尤为明显.
这些发现表明baPWV可能成为癌症患者死亡风险的有价值的预后标志物.

关键词:

动脉硬性动脉硬性癌症癌症癌症癌症癌症恶性瘤是一种恶性瘤.死亡率死亡率

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