在新生儿重症监护病房中比较赫西丁和波维-溶液
Hakan Kucuker1, Salih Cagri Cakir2, Nilgun Koksal2
1Department of Pediatrics, Bursa Uludag University Faculty of Medicine, Bursa, Turkey.
概括
异醇中的赫西丁 (CHG-IA) 对新生儿来说是一种比povidone-iodine (PI) 更安全的替代品. 虽然这两种消毒剂都能同等地预防感染,但CHG-IA没有任何不良影响,也不像PI那样损害甲状腺功能.
科学领域:
- 新生儿护理 新生儿护理
- 预防传染病 预防传染病
- 皮肤病学 皮肤病学
背景情况:
- 在70%的异醇 (CHG-IA) 中含有Povidone-iodine (10%;PI) 和2%的Chlorhexidine是新生儿重症监护室常见的消毒剂.
- 进行了一项比较研究,以确定新生儿应用的优质消毒剂.
研究的目的:
- 为了比较PI和CHG-IA消毒剂在新生儿重症监护病房中的有效性和安全性.
- 评估这些消毒剂对新生儿败血症率,甲状腺功能和不良影响的影响.
主要方法:
- 这是一项随机对照试验,涉及2018年7月至2020年3月期间住院的208名满期和早产婴儿.
- 婴儿在出生前被分配到PI或CHG-IA组,分配的消毒剂用于干预之前的皮肤准备.
- 评估结果包括新生儿败血症率,甲状腺刺激激素 (TSH) 和自由甲状腺素 (fT4) 水平,以及皮肤反应或神经系统副作用的发生率.
主要成果:
- 在PI (8.7%) 和CHG-IA (4.8%) 组 (p=0.406) 之间没有观察到新生儿败血症发生率的显著差异.
- 与CHG-IA组 (3.09 mIU/L) 相比,PI组的婴儿的TSH中位数 (4.05 mIU/L) 显著高于CHG-IA组 (3.09 mIU/L) (p=0.016).
- CHG-IA组报告没有皮肤或神经方面的副作用,而PI组的副作用概况没有详细说明,但暗示不那么有利.
结论:
- 无论PI和CHG-IA都提供了与新生儿感染相比较的保护.
- CHG-IA是新生儿使用的优选消毒剂,因为它具有更安全的不良影响概况,并且对甲状腺功能没有影响.
- 由于PI有可能损害甲状腺功能,因此CHG-IA是新生儿皮肤消毒剂的推替代品.
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