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与CuCF₂CF₃的中断点击反应反应剂:合成5-五乙1,2,3-三醇

Zhengjie Fu¹, Xinkan Yang¹, Gavin Chit Tsui¹

¹Department of Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, 999077 Hong Kong SAR, China.

Organic letters

|June 23, 2023

概括

一种新型的三组分点击反应高效地合成了5-pentafluoroethyl 1,2,3-triazoles. 这种方法利用易于获得的原材料和温和的条件,为化异环提供了一种更环保的方法.

科学领域:

有机化学有机化学
化学的化学
点击化学点击化学 .

背景情况:

1,2,3-三醇是重要的异环化合物,具有多种应用.
有效合成化有机分子仍然是一个重大挑战.
现有的合成化三醇的方法通常涉及恶劣的条件或多个步骤.

研究的目的:

开发一种新的一步方法来合成5 - 五甲1,2,3-三醇.
为了利用一个新的铜试剂从五甲衍生的点击反应.
为了建立温和和环保的反应条件.

主要方法:

采用了三组分的中断点击反应.
随时可用的终端基和亚酸被用作起始材料.
一种关键的试剂[CuCF2CF3]是从五甲制备出来的,用于促进循环添加.

主要成果:

新型的5-pentafluoroethyl 1,2,3-triazoles是在单个步骤中合成的.
铜试剂表现出直角反应性,有利于循环添加而不是激素通路.
反应在温和条件下进行,使用空气作为绿色氧化剂.

结论:

已经实现了 5-pentafluoroethyl 1,2,3-triazoles 的简单高效的一步合成.
开发的方法为有价值的化异环提供了更绿色和更容易获得的途径.
这种方法扩大了点击化学在复杂化分子合成中的实用性.

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