预先存在的免疫力驱动了对食道腺癌中新辅助化疗的反应
Giuseppina Arbore1,2, Luca Albarello3, Gabriele Bucci4
1Experimental Immunology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Cancer research
|June 23, 2023
概括
在食道腺癌 (EAC) 中先前存在的免疫力预测了对新辅助化疗 (nCT) 的反应. 识别这些免疫特征可以帮助分层患者进行量身定制的治疗,并改善生存结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 基因组学就是基因组学.
背景情况:
- 局部晚期食道腺癌 (EAC) 治疗依赖于新辅助化疗 (nCT),病理完整反应率有限 (<30%).
- 了解nCT反应机制对于患者分层和开发更有效的疗法至关重要.
研究的目的:
- 研究局部发达EAC患者对nCT反应的潜在免疫机制.
- 识别用于分层患者和指导治疗策略的预测性免疫特征.
主要方法:
- 治疗前瘤活检和68名EAC患者的血液的多维分析 (34个前性,34个后性).
- 完整响应者与未响应者之间的免疫特征的比较. nCT.
- 对瘤透免疫细胞,全身免疫细胞频率和血细胞因子水平的分析.
主要成果:
- 完全反应者表现出增强的抗瘤CD8+T细胞反应 (CD39+CD103+) 和减少的免疫抑制细胞 (T调节细胞,M2巨细胞).
- 系统分析显示,在反应者中,免疫刺激细胞较高,PD-L1+单细胞髓衍生的抑制细胞减少.
- 血细胞因子概况显示,响应者具有较高的促炎GM-CSF和较低的抑制性细胞因子 (IL4,CXCL10,C3a,C5a),与透瘤的T细胞相关.
结论:
- 以前存在的瘤免疫力显著驱动局部发达EAC中的nCT的临床活性.
- 预测性免疫特征可能会对个性化新辅助和/或辅助疗程的患者进行分层.
- 针对已识别的耐药性分子途径可能会改善EAC患者的临床结果.
相关概念视频
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
208
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
208
Tumor Immunotherapy
575
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
575
Cytotoxic T Cells-mediated Immune Response
998
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
998
Cell-mediated Immune Responses
69.1K
Overview
69.1K


