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类似TTP综合征及其与COVID-19重症患者补充激活的关系:一个横截面研究
Mohammadreza Ardalan1, Mohammadreza Moslemi1, Azin Pakmehr2
1Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Heliyon
|June 23, 2023
概括
血栓性血栓塞性紫花样综合征 (TTPS) 影响9.1%的重症COVID-19患者. 这些患者的较低C3补充水平表明,补充激活在COVID-19期间在TTPS发展中发挥作用.
科学领域:
- 关键护理医学 关键护理医学
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
背景情况:
- 随着COVID-19大流行,血栓栓塞事件的发生率有所增加,包括血栓性血栓塞性紫外线 (TTP).
- 补充系统的激活越来越多地与TTP和TTP类综合征有关.
- 补充剂在COVID-19相关的TTP类综合征中的患病率和作用需要进一步调查.
研究的目的:
- 为了确定重症COVID-19患者中TTP类综合征的患病率.
- 在这个患者群体中,研究TTP类综合征与补充活性 (C3,C4,CH50) 之间的关联.
主要方法:
- 这项研究包括77名重症COVID-19患者被送往ICU.
- 基于血栓缩,微血管病变性血液溶解和末端器官损伤诊断的TTP类综合征.
- 测量了补充水平 (C3,C4,CH50);由于后勤限制,没有评估ADAMTS13活动.
主要成果:
- 七名患者 (9.1%) 被诊断出患有类似TTP的综合征.
- 与没有TTP类综合征的患者相比,TTP类综合征患者的C3水平显著降低 (p=0.014).
- 两组之间没有观察到C4或CH50水平的显著差异.
结论:
- 类似TTP的综合征是重症COVID-19患者的一个显著并发症.
- 降低的C3水平表明补充激活是COVID-19中TTPS的潜在贡献因素.
- 需要进一步的研究来阐明精确的机制,并开发有针对性的疗法.
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