从差异化甲状腺癌中发生的下垂体转移:系统性审查
Nosakhare Paul Ilerhunmwuwa1, Mustafa Wasifuddin1, Jamal Perry1
1Internal Medicine Department, Brookdale Hospital Medical Center/One Brooklyn Health, Brooklyn, NY, USA.
World journal of oncology
|June 23, 2023
概括
从差异化甲状腺癌中发生的垂体转移很少见,乳头甲状腺癌是最常见的. 存活率有限,症状完全消失不常见,需要进一步研究治疗疗效和存活预测因素.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 神经外科 神经外科
背景情况:
- 由差异化甲状腺癌 (DTC) 引起的垂体转移 (PM) 是一个非常罕见的临床事件.
- 细分泌物可以显著影响患者的预后和治疗结果.
- 了解DTC中PM的特征和结果对于改善患者护理至关重要.
研究的目的:
- 系统地审查和评估由差异化甲状腺癌引起的垂体转移患者的临床特征.
- 评估从DTC诊断出PM的患者的结局和生存模式.
- 为了确定常见的表现,内分泌异常,以及来自DTC的PM的治疗方式.
主要方法:
- 在PubMed,Embase和Scopus数据库中进行了系统的文献审查.
- 包括1967年至2022年关于PM和DTC组织学类型 (乳头细胞,卵泡细胞,Hurthle细胞) 的出版物.
- 从PM的初始治疗到死亡或最后的随访,按照PRISMA指南计算了生存时间.
主要成果:
- 25篇文章报告了27例DTC的PM病例,主要是女性 (66.7%) 患有乳头甲状腺癌 (55.6%).
- 常见的症状包括头痛,恶心,吐和视力障碍 (44.4%),而无味糖尿病很少见 (7.4%).
- 平均存活时间为12个月,死亡率为30%,只有33.3%的人实现了完全的症状消失;高血是最常见的内分泌异常 (63.2%).
结论:
- 来自DTC的垂体转移是罕见的,赫特尔细胞癌显示的联系最小.
- 无味糖尿病是一种不常见的初始表现,完全症状的消失是罕见的.
- 虽然老年可能与更好的生存率相关,但需要进行更大规模的研究来证实这一点,并确定生存预测因素和最佳治疗策略.
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